Evaluation of Endocan Serum Level as a Marker of Cardiovascular Risk in Children on Maintenance Hemodialysis.

Document Type : Original Article


1 Pediatric Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

2 Clinical Pathology Department, National Heart Institute, Cairo, Egypt.

3 Radiology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.


Introduction:  Chronic kidney disease (CKD) patients have a higher risk of premature death, mainly due to cardiovascular reasons. Endocan plays a crucial role in causing endothelial dysfunction and inflammation, which makes it a valuable biomarker for detecting cardiovascular disease prognosis. 
Aim of the study: This study aims to investigate the correlation between Endocan levels in the serum of children undergoing hemodialysis and intimal-medial thickness (IMT) and peak systolic velocity of the main arteries. 
Methods:  A comprehensive analysis was conducted to evaluate serum levels of endocan, intimal medial thickness, and peak systolic velocity using Doppler ultrasound, in addition to routine laboratory investigations.
Results: Children who underwent hemodialysis had higher endocan levels than the control group; the median and (IQR) of endocan serum levels were 144.35 (122.2 – 247.55 pg/ml) and 61 (29.05 – 108.8 pg/ml), respectively (P<0.01). The hemodialysis group showed a significant increase in the intima-media thickness (IMT) of the carotid, ulnar, and femoral arteries. Moreover, there was a substantial decrease in the peak systolic velocity (PSV) of the carotid and ulnar arteries in the hemodialysis group. The study also found a positive correlation between the levels of endocan and C-reactive protein (CRP) and the IMT of the carotid, ulnar, and femoral arteries.
Conclusion: Children undergoing hemodialysis displayed elevated endocan levels, significantly associated with increased IMT in major arteries. Endocan plays a significant role in developing and propagating atherosclerosis, thereby increasing the risk of cardiovascular disease.


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