Osteocalcin Level in Children with Nephrotic Syndrome.

Document Type : Original Article

Authors

1 Department of Pediatrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

2 Faculty of Medicine, Fayoum University, Fayoum, Egypt.

3 Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Abstract

Introduction: Nephrotic syndrome is the predominant glomerular disorder in pediatric patients. Increased permeability across the glomerular filtration barrier is a consequence of renal disorders. It is often distinguished by four clinical characteristics: The presence of proteinuria, hypoalbuminemia, edema, and hyperlipidemia within the nephrotic range.
Aim of the Study: The objective of this study was to measure serum osteocalcin (S-OC) level in children with nephrotic syndrome attending Pediatric Nephrology Clinic & General Pediatric Clinic at our University Hospital from March 2021 to March 2022.
Methods: This case – control study was done at our University Hospital on 60 patients with nephrotic syndrome and 20 matched healthy children as control group who were between 2 to 12 years old, blood sample was collected in sterile EDTA tubes and shifted to the hospital laboratory to be separated and measured by ELISA technique.  Normal S-OC level is 50–150ng/mL in children.
Results: we studied 60 children with nephrotic syndrome on steroid therapy,40 (66,7%) were males. There were lower level of total , ionized calcium and higher level of S-OC, positive correlation with p-value <0.05 between steroid duration of treatment and patients weight.
Conclusion: The increase in osteocalcin levels is exclusively determined by the dosage of glucocorticoids, rather than the specific kind of glucocorticoids used. This finding potentially has significant therapeutic significance and has the potential to mitigate bone-related adverse effects. In the majority of instances, the growth parameter of height remains unaffected by many sessions of steroid medication, mostly owing to the administration of vitamin D supplements. 
Use of S-OC as screening tool is not recommended in children on steroid therapy because the increasing in serum osteocalcin level may be due to bone turnover or bone formation.

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