Diagnostic Value of Urinary Heparin Binding Protein in Urinary Tract Infection in Children

Document Type : Original Article

Authors

1 Department of Pediatrics, Mansoura University Children’s hospital, Faculty of Medicine, Mansoura University, Egypt.

2 Department of Clinical Pathology, Faculty of medicine, Mansoura University, Egypt.

Abstract

Introduction
Urinary tract infection is one of the most common bacterial infection in infants and children, diagnosis can be missed or delayed as urine cultures are time consuming. 
 
Aim of the Study
Our aim is to assess the sensitivity and specificity of urinary heparin binding protein (U-HBP) in diagnosis of Urinary tract infection.
 
Methods
Acute febrile children with core temperature ≥ 38 for less than 1 week were enrolled, from 1 month to 3 years from January to May 2016. Urinary HBP levels were assessed by ELISA in the supernatant stored aliquots of centrifuged freshly voided urine. Data was analyzed using SPSS 21. 
 
Results
We found that median levels of U-HBP, were significantly higher in positive focus group in comparison to negative with  p value < 0.001, and that there's a significant relationship between the U-HBP and urine culture (gold standard) with good positive and negative predictive value. 
 
Conclusion
Urinary heparin binding protein can be used as reliable biomarker for the detection of UTI at level 650 picogram/ml in infants and children with sensitivity (72.7%) and specificity (81.2%).
 

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