Effect of High Flux Versus Low Flux Hemodialysis on Some Cardiovascular Risk Factors in Egyptian Children with End Stage Renal Disease.

Badawy, Ahlam; Nigm, Dalia; Farghaly, Hekma; Gamal, Yasser

doi:10.21608/geget.2019.38020

Effect of High Flux Versus Low Flux Hemodialysis on Some Cardiovascular Risk Factors in Egyptian Children with End Stage Renal Disease.

Document Type : Original Article

Authors

¹ Pediatric Department, Pediatric Nephrology Unit, Faculty of Medicine, Assiut University, Egypt.

² Clinical Pathology Department, Faculty of Medicine, Assiut University, Egypt.

³ Pediatric Department, Faculty of Medicine, Assiut University, Egypt.

⁴ Pathology Department, Faculty of Medicine, Assiut University, Egypt.

10.21608/geget.2019.38020

Abstract

Background
Cardiovascular disease   remains as the main cause of mortality in children with end stage renal disease (ESRD).Among the cardiovascular risk factors, dyslipidemia and inflammation are of great importance as they are both prevalent and    modifiable risk factors. We aim to evaluate   the effect of permeability of low-flux versus high-flux dialyzer on such 2 factors in children on regular hemodialysis (HD).

Patients and Methods
48 children with ESRD were randomized into 2 groups. Group A used low-ﬂux dialyzer, group B used   high-ﬂux dialyzer for 6 months. An initial and 6th month blood samples   for   lipid profile, serum albumin and serum high sensitivity CRP (hs CRP) were obtained. Statistical analysis was done.

Results
In the high flux group, there was a statistically significant   difference   in total cholesterol, HDL-cholesterol, triglyceride   and hs CRP   levels after 6 months when compared to baseline values of the same group, while LDL cholesterol and serum albumin   showed no significant change. In the low flux group, results   after 6 months   didn’t show significant change   in previously mentioned parameters when compared with its baseline values of   the same group. Comparing these parameters   between the 2 groups at 6 months, shows that high flux group has significantly lower total cholesterol, triglyceride, and hs CRP levels.

Conclusion
This study has demonstrated for the first time   improvement of some markers of dyslipidemia and inflammation by using high-flux HD in children with ESRD. These results suggest that high-flux dialysis may benefit such young suffering population by reducing the atherogenic risk, cardiovascular morbidity and mortality.

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