Urinary CD25 as a Biomarker of Lupus Nephritis Activity in Pediatrics

Salam, Mohamed; Tawfeek, Doaa M; Mobasher, Eslam S; Khalifa, Nagla A.; El Shafaei, Maher

doi:10.21608/geget.2019.38029

Urinary CD25 as a Biomarker of Lupus Nephritis Activity in Pediatrics

Document Type : Original Article

Authors

¹ Departments of Pediatrics, Faculty of Medicine, Zagazig University, Egypt.

² Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt.

³ Microbiology and Immunology, Faculty of Medicine, Zagazig University, Egypt.

10.21608/geget.2019.38029

Abstract

Background
Lupus nephritis is one of the most serious manifestations of Systemic lupus erythematosus. Proteinuria, complement level, anti-dsDNA and creatinine are the most widely used to assess activity.

Aim of Work
The aim of this study was to assess the relationship of urinary s CD25 with lupus nephritis activity as a noninvasive biomarker in children.

Patients and Methods
The study was conducted on 30 patients divided into 2 groups; Group I: 20 patients of SLE, subdivided into 2 subgroups according to presence of lupus nephritis and Group II: 10 healthy subjects as a control group. Urinary sCD25 was measured in both groups.

Results
Urinary sCD25 was significantly higher in active LN in comparison to inactive and controls. Urinary s CD25 level was correlated with SLE activity, proteinuria and blood urea.

Conclusion Urinary sCD25 is a useful noninvasive technique for assessment of lupus nephritis as it shows a good correlation with some clinical and laboratory parameters of disease relapse.

Keywords

Main Subjects